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Watercress inhibits human CYP2E1 activity in vivo as measured by chlorzoxazone 6-hydroxylation.

✍ Scribed by Kim, R.B.; Wilkinson, G.R.

Book ID
110019601
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
147 KB
Volume
59
Category
Article
ISSN
0009-9236

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Chlormethiazole is a sedative and anticonvulsive drug used in the treatment of alcohol withdrawal. Because it had been reported that chlormethiazole inhibits the alcohol-inducible cytochrome P450 2E1 in rat liver, we investigated the in vivo and in vitro effect of this drug on cytochrome P450 2E1 in