Chlormethiazole is a sedative and anticonvulsive drug used in the treatment of alcohol withdrawal. Because it had been reported that chlormethiazole inhibits the alcohol-inducible cytochrome P450 2E1 in rat liver, we investigated the in vivo and in vitro effect of this drug on cytochrome P450 2E1 in
β¦ LIBER β¦
Cytochrome P450 2E1 activity in diabetic and obese patients as assessed by chlorzoxazone hydroxylation
β Scribed by D Lucas; C Farez; LG Bardou; J Vaisse; JR Attali; P Valensi
- Book ID
- 111193708
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 538 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0767-3981
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The steady-state disposition of chlorzoxazone (CZX) and its hydroxylated metabolite 6-hydroxychlorzoxazone (HCZX) was determined in a single-pass isolated perfused rat liver (IPRL) model using constant CZX concentrations of 10-200 microM. The concentrations of CZX, HCZX, and/or HCZX glucuronide in t