En soumettant la mkthylkne-asparagine (I) a la reaction de Hofmann (traitement a l'hypobromite) dans le but de la transformer en un derive de l'acide diamino-propionique, nous avons obtenu un acide halogene C,H,03N,Br. La constitution de ce corps pouvait 6tre interpretke de deux manihres. Les produ
Voies Nouvelles en Synthèse de Prostaglandins (1)
✍ Scribed by P. Crabbé; E. Barreiro; H. Sook Choi; A. Cruz; J. P. Deprès; G. Gagnaire; A. E. Greene; M. C. Meana; A. Padilla; L. Williams
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2010
- Weight
- 646 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0037-9646
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✦ Synopsis
Abstract
The preparation of novel prostaglandin analogues from PGA~2~, isolated from marine corals, is outlined.
The synthesis of prostaglandins that contain a cyclobutane instead of the cyclopentane ring is described.
In addition, a detailed account of the total synthesis of prostaglandins by the tropolone route is given.
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