✦ LIBER ✦

Nouvelle synthèse de la Bradykinine

✍ Scribed by St. Guttmann; J. Pless; R. A. Boissonnas

Publisher: John Wiley and Sons
Year: 1962
Tongue: German
Weight: 609 KB
Volume: 45
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19620450120

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

An improved synthesis of Bradykinin is described. N‐CBO‐G‐tosyl‐L‐arginyl‐L‐prolyl‐L‐prolyl‐glycine p‐nitrophenyl ester and L‐phenylalanyl‐L‐seryl‐L‐prolyl‐L‐phenylalanyl‐G‐tosyl‐L‐arginine are prepared and condensed together to N‐CBO‐G‐tosyl‐L‐arginyl‐L‐prolyl‐L‐prolyl‐glycyl‐L‐phenylalanyl‐L‐seryl‐L‐prolyl‐L‐phenylalanyl‐G‐tosyl‐L‐arginine. Removal of the protective groups by sodium in liquid ammonia affords directly pure Bradykinin in high yield.

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