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Vitamin E decreases valproic acid induced neural tube defects in mice

✍ Scribed by Saleh Al Deeb; Khalaf Al Moutaery; Mohammed Arshaduddin; Mohammad Tariq

Book ID: 117471108
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 76 KB
Volume: 292
Category: Article
ISSN: 0304-3940
DOI: 10.1016/s0304-3940(00)01457-9

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## BACKGROUND: Valproic acid (VPA) causes the failure of neural tube closure in newborn mice. However, the molecular mechanism of its teratogenesis is unknown. This study was conducted to investigate the genomewide effects of VPA disruption of normal neural tube development in mice. METHODS: Micro