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Methotrexate increases valproic acid-induced developmental toxicity, in particular neural tube defects in mice

✍ Scribed by M. M. A. Elmazar; Dr. H. Nau

Book ID: 112213523
Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 464 KB
Volume: 12
Category: Article
ISSN: 0270-3211
DOI: 10.1002/tcm.1770120503

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## BACKGROUND: Valproic acid (VPA) causes the failure of neural tube closure in newborn mice. However, the molecular mechanism of its teratogenesis is unknown. This study was conducted to investigate the genomewide effects of VPA disruption of normal neural tube development in mice. METHODS: Micro