Ethanol potentiates valproic acid-induced neural tube defects (NTDs) in mice due to toxicokinetic interactions
β Scribed by Mohamed M.A. Elmazar; Heinz Nau
- Book ID
- 113384406
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 803 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0890-6238
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## BACKGROUND: Valproic acid (VPA) causes the failure of neural tube closure in newborn mice. However, the molecular mechanism of its teratogenesis is unknown. This study was conducted to investigate the genomewide effects of VPA disruption of normal neural tube development in mice. METHODS: Micro
Neural tube defects (NTDs), although prevalent and easily diagnosed, are etiologically heterogeneous, rendering mechanistic interpretation problematic. To date, there is evidence that mammalian neural tube closure (NTC) initiates and fuses intermittently at four discrete locations. Disruption of thi