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Carnitine and Coenzyme A Decrease Valproic Acid-Induced Neural Tube Defects in Mice

✍ Scribed by Tetsuji NAGAO; Mariko SHIROTA; Masako SATO

Book ID: 114825175
Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 572 KB
Volume: 36
Category: Article
ISSN: 0914-3505
DOI: 10.1111/j.1741-4520.1996.tb00622.x

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## BACKGROUND: Valproic acid (VPA) causes the failure of neural tube closure in newborn mice. However, the molecular mechanism of its teratogenesis is unknown. This study was conducted to investigate the genomewide effects of VPA disruption of normal neural tube development in mice. METHODS: Micro