Vincristine-resistant Human Cancer KB Cell Line and Increased Expression of Multidrug-resistance Gene
β Scribed by Kohno, Kimitoshi ;Kikuchi, Junko ;Sato, Shin-ichi ;Takano, Hiroshi ;Saburi, Yoshio ;Asoh, Kuni-ichi ;Kuwano, Michihiko
- Book ID
- 108578683
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1988
- Tongue
- English
- Weight
- 424 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0910-5050
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In addition to P-glycoprotein (Pgp), 2 proteins related to multidrug resistance (MDR) have recently been described. The Multidrug-Resistance-associated protein (MRP) is one of the ATP-binding-cassette (ABC) transporters. The Lung-Resistance Protein (LRP) is the major component of human vaults, which
## Abstract In order to understand the molecular mechanisms of multidrug resistance (MDR) in ovarian cancer, we employed the proteomic approach of isobaric tags for relative and absolute quantification (iTRAQ), followed by LCβMS/MS, using the cisplatinβresistant COC1/DDP cell line and its parental