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VHL loss of function and its impact on oncogenic signaling networks in clear cell renal cell carcinoma

✍ Scribed by W. Marston Linehan; Jeffrey S. Rubin; Donald P. Bottaro


Book ID
116307692
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
441 KB
Volume
41
Category
Article
ISSN
1357-2725

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Inactivation of tumour suppressor gene(s) (TSGs) on 3p appears to be a critical event in the pathogenesis of clear cell renal cell carcinoma (CC-RCC). Analysis of loss of heterozygosity (LOH) in sporadic RCC samples has implicated roles for TSGs in three specific regions of 3p in RCC development: (1