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Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A , and JARID1c in clear cell renal cell carcinoma

✍ Scribed by Gossage, Lucy; Murtaza, Muhammed; Slatter, Andrew F.; Lichtenstein, Conrad P.; Warren, Anne; Haynes, Beverley; Marass, Francesco; Roberts, Ian; Shanahan, Susan J.; Claas, Andreas; Dunham, Andrew; May, Andrew P.; Rosenfeld, Nitzan; Forshew, Tim; Eisen, Tim

Book ID: 121345612
Publisher: John Wiley and Sons
Year: 2013
Tongue: English
Weight: 241 KB
Volume: 53
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.22116

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Background: Historically, VHL was the only frequently mutated gene in clear cell renal cell carcinoma (ccRCC), with conflicting clinical relevance. Recent sequencing efforts have identified several novel frequent mutations of histone modifying and chromatin remodeling genes in ccRCC including PBRM1,