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Clinical and Pathologic Impact of Select Chromatin-modulating Tumor Suppressors in Clear Cell Renal Cell Carcinoma

✍ Scribed by Hakimi, A. Ari; Chen, Ying-Bei; Wren, James; Gonen, Mithat; Abdel-Wahab, Omar; Heguy, Adriana; Liu, Han; Takeda, Shugaku; Tickoo, Satish K.; Reuter, Victor E.; Voss, Martin H.; Motzer, Robert J.; Coleman, Jonathan A.; Cheng, Emily H.; Russo, Paul; Hsieh, James J.

Book ID
121230375
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
704 KB
Volume
63
Category
Article
ISSN
0302-2838

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Clinical and Pathologic Impact of Select
Clinical and Pathologic Impact of Select Chromatin-modulating Tumor Suppressors in Clear Cell Renal Cell Carcinoma
✍ Hakimi, A. Ari; Chen, Ying-Bei; Wren, James; Gonen, Mithat; Abdel-Wahab, Omar; H πŸ“‚ Article πŸ“… 2013 πŸ› Elsevier Science 🌐 English βš– 704 KB

Background: Historically, VHL was the only frequently mutated gene in clear cell renal cell carcinoma (ccRCC), with conflicting clinical relevance. Recent sequencing efforts have identified several novel frequent mutations of histone modifying and chromatin remodeling genes in ccRCC including PBRM1,