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The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma

โœ Scribed by Yuen, J S P; Cockman, M E; Sullivan, M; Protheroe, A; Turner, G D H; Roberts, I S; Pugh, C W; Werner, H; Macaulay, V M

Book ID
110072470
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
289 KB
Volume
26
Category
Article
ISSN
0950-9232

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Germline mutations in the von Hippel-Lindau (VHL) disease tumor suppressor gene (TSG) convey a high risk of clear-cell renal-cell carcinoma (CC-RCC) and most sporadic CC-RCCs demonstrate somatic inactivation of the VHL TSG. However, the existence of further CC-RCC gatekeeper genes is implied by CC-R