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Vertebrate POLQ and POLβ Cooperate in Base Excision Repair of Oxidative DNA Damage

✍ Scribed by Michio Yoshimura; Masaoki Kohzaki; Jun Nakamura; Kenjiro Asagoshi; Eiichiro Sonoda; Esther Hou; Rajendra Prasad; Samuel H. Wilson; Keizo Tano; Akira Yasui; Li Lan; Mineaki Seki; Richard D. Wood; Hiroshi Arakawa; Jean-Marie Buerstedde; Helfrid Hochegger; Takashi Okada; Masahiro Hiraoka; Shunichi Takeda


Book ID
116754308
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
580 KB
Volume
24
Category
Article
ISSN
1097-2765

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## Abstract Oxidative damage represents the most significant insult to organisms because of continuous production of the reactive oxygen species (ROS) in vivo. Oxidative damage in DNA, a critical target of ROS, is repaired primarily via the base excision repair (BER) pathway which appears to be the