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Base excision repair of oxidative DNA damage and association with cancer and aging

✍ Scribed by Maynard, S.; Schurman, S. H.; Harboe, C.; de Souza-Pinto, N. C.; Bohr, V. A.

Book ID: 111879778
Publisher: Oxford University Press
Year: 2008
Tongue: English
Weight: 178 KB
Volume: 30
Category: Article
ISSN: 0143-3334
DOI: 10.1093/carcin/bgn250

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## Abstract Oxidative damage represents the most significant insult to organisms because of continuous production of the reactive oxygen species (ROS) in vivo. Oxidative damage in DNA, a critical target of ROS, is repaired primarily via the base excision repair (BER) pathway which appears to be the