Spontaneous mutation, oxidative DNA dama
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Andrew D. Scott; Maryam Neishabury; D. Hugh Jones; Simon H. Reed; Serge Boiteux;
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Article
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1999
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John Wiley and Sons
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English
β 315 KB
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The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine (8-OxoG). When compared to wild-type, ogg1 mutants show an increase in the frequency of GC to TA transversions, indicating a role for Ogg1 in the repair of 8-OxoG. Here we report an increased fr