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P.2.d.035 Base excision repair and oxidative DNA damage in patients with bipolar disorder

✍ Scribed by Özalp, D. Ceylan Tufan; Tuna, G.; Kirkali, G.; Tunca, Z.; Dizdaroglu, M.; Can, G.; Arat, H.E.; Ozerdem, A.


Book ID
127142918
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
75 KB
Volume
24
Category
Article
ISSN
0924-977X

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The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine (8-OxoG). When compared to wild-type, ogg1 mutants show an increase in the frequency of GC to TA transversions, indicating a role for Ogg1 in the repair of 8-OxoG. Here we report an increased fr