We have been examining synthetic approaches to spiroketal rings of types 1 and 2, structural units common to a wide variety of natural products including steroid sapogenins,2 oligomycins, 3 milbemycins,4 and many polyether antibiotics, e.g., monensin5 and antibiotic ## A231876 During the course o
✦ LIBER ✦
Versatile synthesis of α, β-acetylenic ketones by oxidative nucleophilic addition of vanadium acetylides
✍ Scribed by Toshikazu Hirao; Daisuke Misu; Toshio Agawa
- Book ID
- 104218255
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 126 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
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g-Hydroxy-a,b-acetylenic esters containing three adjacent and structurally very different functional groups are very useful in the synthesis of highly functionalized organic molecules. [1, 2] This class of compound is normally prepared by treatment of an alkyl propiolate with nBuLi at À78 8C