Highly Enantioselective Synthesis of γ-Hydroxy-α,β-acetylenic Esters by Asymmetric Alkyne Addition to Aldehydes

✍ Scribed by Ge Gao; Qin Wang; Xiao-Qi Yu; Ru-Gang Xie; Lin Pu

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 114 KB
• Volume: 118
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/ange.200500469

✦ Synopsis

g-Hydroxy-a,b-acetylenic esters containing three adjacent and structurally very different functional groups are very useful in the synthesis of highly functionalized organic molecules. [1, 2] This class of compound is normally prepared by treatment of an alkyl propiolate with nBuLi at À78 8C