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Highly Enantioselective Michael Addition of Cyclic 1,3-Dicarbonyl Compounds to β,γ-Unsaturated α-Keto Esters

✍ Scribed by Xing-Kuan Chen; Chang-Wu Zheng; Sheng-Li Zhao; Zhuo Chai; Ying-Quan Yang; Gang Zhao; Wei-Guo Cao


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
219 KB
Volume
352
Category
Article
ISSN
1615-4150

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g-Hydroxy-a,b-acetylenic esters containing three adjacent and structurally very different functional groups are very useful in the synthesis of highly functionalized organic molecules. [1, 2] This class of compound is normally prepared by treatment of an alkyl propiolate with nBuLi at À78 8C