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V(D)J Recombination: Double-Strand Break Repair Gene Products Used in the Joining Mechanism

✍ Scribed by DAVID WEAVER; NIKOLAI BOUBNOV; ZACHARY WILLS; KATHRYN HALL; JANE STAUNTON


Book ID
119872551
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
708 KB
Volume
764
Category
Article
ISSN
0890-6564

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The end-joining pathway of DNA double-strand break (DSB) repair is necessary for proper V(D)J recombination and repair of DSB caused by ionizing radiation. This DNA repair pathway can either use short stretches of (micro)homology near the DNA ends or use no homology at all (direct end-joining). We d