DNA Ligase IV Is Essential for V(D)J Recombination and DNA Double-Strand Break Repair in Human Precursor Lymphocytes
โ Scribed by Ulf Grawunder; David Zimmer; Sebastian Fugmann; Klaus Schwarz; Michael R. Lieber
- Book ID
- 117736119
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 124 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1097-2765
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The end-joining pathway of DNA double-strand break (DSB) repair is necessary for proper V(D)J recombination and repair of DSB caused by ionizing radiation. This DNA repair pathway can either use short stretches of (micro)homology near the DNA ends or use no homology at all (direct end-joining). We d