Equine SCID: a defect in V(D)J recombination, double strand break repair and DNA-dependent protein kinase activity
β Scribed by Rhonda Wiler; Ray Leber; Bethany B. Moore; Linda F. VanDyk; Lance E. Perryman; Katheryn Meek
- Book ID
- 117336456
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 55 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0165-2427
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The initial step of the V(D)J recombination occurs through the generation of a DNA double-strand break (dsb). Defects in the DNA-dependent protein kinase complex (DNA-PK) result in an inability to perform either V(D)J recombination or any dsb repair effectively. The human autosomal T-B-severe combin
the rearrangement process through the recognition of and Jean-Pierre de Villartay\* the RSS and the introduction of a DNA double-strand \* De Β΄veloppement Normal et Pathologique break (dsb) at the border of the heptamer (Schatz et du Syste `me Immunitaire al., 1989; Oettinger et al., 1990). The subs
The end-joining pathway of DNA double-strand break (DSB) repair is necessary for proper V(D)J recombination and repair of DSB caused by ionizing radiation. This DNA repair pathway can either use short stretches of (micro)homology near the DNA ends or use no homology at all (direct end-joining). We d