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Variation in transcriptional regulation of cyclin dependent kinase inhibitor p21waf1/cip1among human bronchogenic carcinomas

โœ Scribed by Michael W Harr; Timothy G Graves; Erin L Crawford; Kristy A Warner; Cheryl AM Reed; James C Willey

Book ID
119901918
Publisher
BioMed Central
Year
2005
Tongue
English
Weight
615 KB
Volume
4
Category
Article
ISSN
1476-4598

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โœ J H Albrecht; A H Meyer; M Y Hu ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 817 KB

WAF1/Cip1/Sdi1 (p21) is the prototype of a family of proteins that inhibit cyclin-dependent kinases and regulate cell cycle progression in eukaryotic cells. In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbet