Ataxia-telangiectasia (A-T) is an autosomal recessive disease involving chromosomal instability, susceptibility to cancer and X-ray hypersensitivity. The latter two features are expressed to a limited extent in the heterozygous carriers of A-T mutations. Although fibroblast lines from A-T heterozygo
Variant of ataxia-telangiectasia with low-level radiosensitivity
โ Scribed by M. Fiorilli; A. Antonelli; G. Russo; M. Crescenzi; M. Carbonari; P. Petrinelli
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 423 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0340-6717
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X-ray induced chromosomal aberrations in peripheral blood lymphocytes as well as in skin fibroblasts from ataxia telangiectasia patients, and from normal individuals were studied. At all stages of cell cycles-namely G0, G1, and G2, more aberrations were induced in AT cells than in normal cells. In a
## Abstract In this study EpsteinโBarr virusโtransformed lymphoblastoid cells were shown to contain fibronectin. A marked difference in the number of fibronectinโpositive cells was observed in control and ataxiaโtelangiectasia lymphoblastoid cells. Three control cell lines varied between 60% and 80