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Chromosomal radiosensitivity of ataxia telangiectasia cells at different cell cycle stages

โœ Scribed by A. T. Natarajan; M. Meyers

Publisher
Springer
Year
1979
Tongue
English
Weight
325 KB
Volume
52
Category
Article
ISSN
0340-6717

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โœฆ Synopsis

X-ray induced chromosomal aberrations in peripheral blood lymphocytes as well as in skin fibroblasts from ataxia telangiectasia patients, and from normal individuals were studied. At all stages of cell cycles-namely G0, G1, and G2, more aberrations were induced in AT cells than in normal cells. In addition, AT cells were sensitive to induction of chromosomal aberrations by tritium beta rays from incorporated radioactive thymidine. Possible reasons for the increased sensitivity of AT cells for induction of chromosomal aberrations by ionizing radiations are discussed.

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