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Reduced levels of fibronectin in ataxia-telangiectasia lymphoblastoid cells

✍ Scribed by Martin F. Lavin; G. J. Seymour

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
531 KB
Volume
33
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

In this study Epstein‐Barr virus‐transformed lymphoblastoid cells were shown to contain fibronectin. A marked difference in the number of fibronectin‐positive cells was observed in control and ataxia‐telangiectasia lymphoblastoid cells. Three control cell lines varied between 60% and 80% in the number of cells containing fibronectin. Only a small percentage of ataxia‐telangiectasia cells (1–5%) had fibronectin present. Control and ataxia‐telangiectasia fibroblasts had similar amounts and distributions of fibronectin. An asymmetric distribution of fibronectin was evident in many control and ataxia‐telangiectasia lymphoblastoid cells. The increased frequency of fibronectin‐containing cells in the control populations cannot be accounted for by different growth rates or variation in the various phases of the cell cycle in the two cell types.

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