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Clonal evolution of T-cell chronic lymphocytic leukaemia in a patient with ataxia telangiectasia

โœ Scribed by A. M. R. Taylor; S. V. Butterworth

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
746 KB
Volume
37
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

Ataxia telangiectasia (A-T) is an autosomal recessive disorder in which patients show an unusual predisposition to malignant disease, including T-cell chronic lymphocytic leukaemia. We report here the steady growth over 5 years of a complex, cytogenetically abnormal clone of T lymphocytes in an A-T patient who was subsequently found to have an OKT3/OKT8 chronic lymphocytic leukaemia. The tumour cells at diagnosis had clearly evolved from a pre-existing, cytogenetically abnormal T-cell clone which contained an inv(l4) chromosomal inversion alone.

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