The chromosomal translocation t(11;14)(q13;q32) fuses the IGH and CCND1 genes and leads to cyclin D1 overexpression. This genetic abnormality is the hallmark of mantle cell lymphoma (MCL), but is also found in some cases of atypical chronic lymphocytic leukemia (CLL), characterized by a poor outcome
Cytogenetic and molecular characterization of a patient with simultaneous B-cell chronic lymphocytic leukemia and peripheral T-cell lymphoma
✍ Scribed by J. Ignacio Martin-Subero; Reiner Siebert; Lana Harder; Stefan Gesk; Peter Schwindt; Andreas Bräuninger; Klaus Willenbrock; Doris Steinemann; Markus Tiemann; Maria Jose Calasanz; Werner Grote; Wolf-Dieter Ludwig; Martin-Leo Hansmann; Brigitte Schlegelberger
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 290 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0361-8609
- DOI
- 10.1002/ajh.1190
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