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Cytogenetic study of patients with ataxia-telangiectasia

✍ Scribed by N. P. Bochkov; Y. M. Lopukhin; N. P. Kuleshov; L. V. Kovalchuk

Publisher: Springer
Year: 1974
Tongue: English
Weight: 905 KB
Volume: 24
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00283768

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This article summarizes the genetics and clinical features of ataxia telangiectasia (AT) and then reviews recent cytogenetic, cellular, and biochemical studies which support the hypothesis that a defect in DNA repair is responsible for the various manifestations of the disease. The biochemical evide