Variability of 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute leukemia
✍ Scribed by Pierre Lafolie; Olle Björk; Salah Hayder; Lars Åhström; Curt Peterson
- Book ID
- 112962853
- Publisher
- Springer US
- Year
- 1989
- Tongue
- English
- Weight
- 518 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1357-0560
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📜 SIMILAR VOLUMES
Intraindividual variation in 6-mercaptopurine (6-MP) kinetics has been little studied. It has now been examined in 18 children with acute lymphoblastic leukaemia (ALL). On 2 to 4 occasions in each patient drug concentrations in plasma and red cells were followed for 4 h after administration by means
We studied the disposition phannacokinetics of methotrexate (MTX) given orally to 16 children with acute lyrnphoblastic leukemia (ALL) and its relation to the pharrnacokinetics of 6-mercaptopurine (6MP) in the same children. There was an eightfold variability in area-under-concentration tirnecurve (