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Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia

✍ Scribed by Sulh, Hassan; Koren, Gideon; Whalen, Chris; Soldin, Steven; Zipursky, Alvin; Greenberg, Mark

Book ID
109843991
Publisher
Nature Publishing Group
Year
1986
Tongue
English
Weight
410 KB
Volume
40
Category
Article
ISSN
0009-9236

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We studied the disposition phannacokinetics of methotrexate (MTX) given orally to 16 children with acute lyrnphoblastic leukemia (ALL) and its relation to the pharrnacokinetics of 6-mercaptopurine (6MP) in the same children. There was an eightfold variability in area-under-concentration tirnecurve (