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Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia

Book ID
123015162
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
104 KB
Volume
1
Category
Article
ISSN
0891-5245

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We studied the disposition phannacokinetics of methotrexate (MTX) given orally to 16 children with acute lyrnphoblastic leukemia (ALL) and its relation to the pharrnacokinetics of 6-mercaptopurine (6MP) in the same children. There was an eightfold variability in area-under-concentration tirnecurve (