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UV Radiation Is a Transcriptional Inducer of p21Cip1/Waf1Cyclin-Kinase Inhibitor in a p53-Independent Manner

✍ Scribed by Tarja Haapajärvi; Laura Kivinen; Annamari Heiskanen; Charles des Bordes; Michael B. Datto; Xiao-Fan Wang; Marikki Laiho


Book ID
115603223
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
197 KB
Volume
248
Category
Article
ISSN
0014-4827

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✍ Iqbal H. Chowdhury; Arash Farhadi; Xiao-Fan Wang; Merlin L. Robb; Deborah L. Bir 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 342 KB

We investigated the possible involvement of HTLV-1 Tax in the transcriptional activation of p21/Waf1/Cip1 (hereafter p21), a potent inhibitor of cyclin-dependent kinases and cell growth. Tax transfection resulted in enhanced expression of p21 protein in T and fibroblastoid cells. Similarly, Tax-expr