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Utilization of Grignard Reagents in Solid-phase Synthesis: A Review of the Literature

✍ Scribed by Robert G. Franzén

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
268 KB
Volume
56
Category
Article
ISSN
0040-4020

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✦ Synopsis

Reactions of Grignard

Reagents with Polymer-bound Aldehydes and Ketones 686 3. Addition of Grignard Reagents to Polymer-bound Esters 687 4. Other Types of Reactions where Grignard Reagents have been Added to Polymer-bound Compounds 687 5. Grignard Reagents Utilized for Cleavage of Resin-bound Molecules 689 6. Grignard Reagents on an Insoluble Polymer 689 7. Conclusion

📜 SIMILAR VOLUMES

Preparation of Highly Functionalized Gri
Preparation of Highly Functionalized Grignard Reagents by an Iodine–Magnesium Exchange Reaction and its Application in Solid-Phase Synthesis
✍ Laure Boymond; Mario Rottländer; Gérard Cahiez; Paul Knochel 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 107 KB 👁 2 views

At -40°C aryl iodides that contain other functional groups can be selectively converted into Grignard reagents, which react with electrophiles such as benzaldehyde in the usual manner [Eq. (a)]. Aryl bromides and iodides that are immobilized as esters on a Wang resin behave analogously.