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Use of the narrow beam test in the rat, 6-hydroxydopamine model of Parkinson's disease

✍ Scribed by Haydn N. Allbutt; Jasmine M. Henderson

Book ID: 108186361
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 651 KB
Volume: 159
Category: Article
ISSN: 0165-0270
DOI: 10.1016/j.jneumeth.2006.07.006

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## Abstract To investigate the psychiatric symptoms accompanying the early phases of Parkinson's disease (PD), we injected adult rats with 10.5 μg 6‐hydroxydopamine (6‐OHDA) bilaterally into the dorsal striatum. The resulting neurodegeneration led, 12 weeks after injection, to a mild (36%) reductio