The Hydrolysis of Striatal Adenine- and Guanine-Based Purines in a 6-Hydroxydopamine Rat Model of Parkinson’s Disease
✍ Scribed by Jean Pierre Oses; Cristiane Batassini; Daniela Pochmann; Ana Elisa Böhmer; Fernanda Cenci Vuaden; Roberta Bristot Silvestrin; Alcyr Oliveira; Carla Denise Bonan; Maurício Reis Bogo; Diogo Onofre Souza; Luis Valmor Cruz Portela; João José de Freitas Sarkis; Tadeu Mello e Souza
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 328 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0364-3190
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## Abstract To investigate the psychiatric symptoms accompanying the early phases of Parkinson's disease (PD), we injected adult rats with 10.5 μg 6‐hydroxydopamine (6‐OHDA) bilaterally into the dorsal striatum. The resulting neurodegeneration led, 12 weeks after injection, to a mild (36%) reductio
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## Abstract 6‐Hydroxydopamine (6‐OHDA), a neurotoxin that causes the death of dopamine (DA) neurons, is commonly used to produce experimental models of Parkinson's disease (PD) in rodents. In the rat model of PD first described by Sauer and Oertel, DA neurons progressively die over several weeks fo