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Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson’s disease discerned with

✍ Scribed by Nadja Van Camp; Ruth Vreys; Koen Van Laere; Erwin Lauwers; Dirk Beque; Marleen Verhoye; Cindy Casteels; Alfons Verbruggen; Zeger Debyser; Luc Mortelmans; Jan Sijbers; Johan Nuyts; Veerle Baekelandt; Annemie Van der Linden

Publisher
Springer
Year
2010
Tongue
English
Weight
398 KB
Volume
23
Category
Article
ISSN
0968-5243

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Nonmotor symptoms in Parkinson's disease
Nonmotor symptoms in Parkinson's disease: Investigating early-phase onset of behavioral dysfunction in the 6-hydroxydopamine-lesioned rat model
✍ Igor Branchi; Ivana D'Andrea; Monica Armida; Tommaso Cassano; Antonella Pèzzola; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 320 KB 👁 1 views

## Abstract To investigate the psychiatric symptoms accompanying the early phases of Parkinson's disease (PD), we injected adult rats with 10.5 μg 6‐hydroxydopamine (6‐OHDA) bilaterally into the dorsal striatum. The resulting neurodegeneration led, 12 weeks after injection, to a mild (36%) reductio