In this communication we introduce a promising masking agent --the vinyloxycarbonyl or VOC group --for the protection of amino functions in peptide chemistry. Amino acids are easily converted to their N-VOC derivatives (l\_) in dilute aqueous base using the known vinyl chloroformate' in dioxane as t
Use of the excluded protecting group (EPG) method for peptide synthesis
โ Scribed by Head, D.B. ;Dong, J.Z. ;Burton, J.A.
- Book ID
- 110893863
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 175 KB
- Volume
- 65
- Category
- Article
- ISSN
- 1397-002X
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๐ SIMILAR VOLUMES
Acetol can be conveniently used as a reagent for the protection of carboxylic acids in peptide synthesis. It has been found to be inert and stable to hydrogenolytic and acidolytic conditions normally used in peptide synthesis. Deblocking has been selectively achieved under mild conditions using Bu4N
## Abstract We have found a novel way of protecting the hydroxyl function in hydroxyโLโamino acids, making use of the tโbutoxy group, which is readily split by acids, but not by bases. This group is introduced by acidโcatalysed addition of isobutene to Nโacylated hydroxyโLโamino acids. The blockin