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An Amino-Protecting Group for Use in Peptide Synthesis Which Can Be Introduced Electrochemically

✍ Scribed by Dr. Mohamed Hassen Khalifa; Prof. Dr. Günther Jung; Prof. Dr. Anton Rieker

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
263 KB
Volume
19
Category
Article
ISSN
0044-8249

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In this communication we introduce a promising masking agent --the vinyloxycarbonyl or VOC group --for the protection of amino functions in peptide chemistry. Amino acids are easily converted to their N-VOC derivatives (l\_) in dilute aqueous base using the known vinyl chloroformate' in dioxane as t

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## Abstract We have found a novel way of protecting the hydroxyl function in hydroxy‐L‐amino acids, making use of the t‐butoxy group, which is readily split by acids, but not by bases. This group is introduced by acid‐catalysed addition of isobutene to N‐acylated hydroxy‐L‐amino acids. The blockin