Use of polar picolyl protecting groups in peptide synthesis
โ Scribed by Rizo, Josep; Albericio, Fernando; Romero, Guillermo; Garcia-Echeverria, Carlos; Claret, Josep; Muller, Carlos; Giralt, Ernest; Pedroso, Enrique
- Book ID
- 121460422
- Publisher
- American Chemical Society
- Year
- 1988
- Tongue
- English
- Weight
- 592 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
We wish to report our first studies on the possibility of applying the acetoacetyl group CHzCOCHzCC-(AA), to the protection of amino groups in peptide synthesis.
In this communication we introduce a promising masking agent --the vinyloxycarbonyl or VOC group --for the protection of amino functions in peptide chemistry. Amino acids are easily converted to their N-VOC derivatives (l\_) in dilute aqueous base using the known vinyl chloroformate' in dioxane as t