Use of substituted benzyl esters as carboxyl-protecting groups in solid-phase peptide synthesis
β Scribed by Prestidge, Ross L.; Harding, David R. K.; Hancock, William S.
- Book ID
- 126133524
- Publisher
- American Chemical Society
- Year
- 1976
- Tongue
- English
- Weight
- 751 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
The compound A~GlcNACgl-NH-Fmoc (3) was eynthesixed and transformed into the &gluwsyl amine (1) which was subsequently acylated with Fmoc-Asp(CI)-Gpfp (5) prepared from the readily available Fmoc-Asp@-tBu)-G-pfp (4). The resulting Fmoc-Asn(A~GlcNAcfil-N-)-O-Pfp (6) was used as a buildiug block in th
Amino acid derivatives protected at the a-or side chain amino function with mono-as well as dimethoxytrityl were successfully prepared by a one-step procedure. These derivatives were evaluated for their utilization in solid phase peptide synthesis (SPPS), particularly with respect to the selective d