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Use of an in vitro blood-brain barrier model to achieve a fast screening of unlabelled pharmaceuticals

✍ Scribed by Guillot, F.L.; Schluep, C.; Lemaire, M.


Book ID
123265014
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
103 KB
Volume
21
Category
Article
ISSN
0197-0186

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Accumulation of carnitine was studied in immortalized rat brain capillary endothelial cells R B E ~, as an in vitro model of blood-brain barrier. Both uptake and efflux phenomena were found independent on "a+] gradient. A quick acylation of carnitine in RBE4 cells was observed, especially leading to