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Development of a Humanized In Vitro Blood–Brain Barrier Model to Screen for Brain Penetration of Antiepileptic Drugs

✍ Scribed by Luca Cucullo; Mohammed Hossain; Ed Rapp; Toby Manders; Nicola Marchi; Damir Janigro


Book ID
109110209
Publisher
Wiley (Blackwell Publishing)
Year
2007
Tongue
English
Weight
282 KB
Volume
48
Category
Article
ISSN
0013-9580

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Accumulation of carnitine was studied in immortalized rat brain capillary endothelial cells R B E ~, as an in vitro model of blood-brain barrier. Both uptake and efflux phenomena were found independent on "a+] gradient. A quick acylation of carnitine in RBE4 cells was observed, especially leading to