This article describes the experimental set-up and pharmacokinetic modeling of P-glycoprotein function in the rat blood-brain barrier using [ 11 C]verapamil as the substrate and cyclosporin A as an inhibitor of P-gp. [ 11 C]verapamil was administered to rats as an i.v. bolus dose followed by graded
Inhibition of P-Glycoprotein: Rapid Assessment of Its Implication in Blood-Brain Barrier Integrity and Drug Transport to the Brain by an In Vitro Model of the Blood-Brain Barrier
✍ Scribed by Laurence Fenart; Valeric Buée-Scherrer; Laurence Descamps; Christian Duhem; Marie-Gwenaëlle Poullain; Roméo Cecchelli; Marie-Pierre Dehouck
- Book ID
- 110305209
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 782 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0724-8741
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