Use of 11C as a tracer for studying the synthesis of [11C]urea from [11C]cyanide
β Scribed by Thomas E. Boothe; Ali M. Emran; Ronald D. Finn; Manhar M. Vora; Paresh J. Kothari
- Publisher
- Elsevier Science
- Year
- 1985
- Weight
- 438 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0020-708X
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## Abstract Preparation of [^11^C]methyltriphenylphosphonium iodide and the __in situ__ generation of [^11^C]methylenetriphenylphosphorane directly from [^11^C]methyl iodide, is described. Using this oneβpot preparation, [Ξ²β^11^C]styrene was synthesized conveniently, fast and with a minimum of manu
5-(2-Phenylethynyl)pyridine-3-[ 11 C]carbonitrile ([ 11 C]LY2232645), a metabotropic glutamate 5 receptor (mGluR5) antagonist, was synthesized by a no-carrier-added nucleophilic halogen displacement with [ 11 C]copper(I) cyanide. The average radiochemical yield was 2.5%, and the average specific act