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Synthesis of a mGluR5 antagonist using [11C]copper(I) cyanide

✍ Scribed by William B. Mathews; James A. Monn; Hayden T. Ravert; Daniel P. Holt; Darryle D. Schoepp; Robert F. Dannals

Publisher: John Wiley and Sons
Year: 2006
Tongue: French
Weight: 148 KB
Volume: 49
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1100

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✦ Synopsis

5-(2-Phenylethynyl)pyridine-3-[ 11 C]carbonitrile ([ 11 C]LY2232645), a metabotropic glutamate 5 receptor (mGluR5) antagonist, was synthesized by a no-carrier-added nucleophilic halogen displacement with [ 11 C]copper(I) cyanide. The average radiochemical yield was 2.5%, and the average specific activity was 1365 mCi/mmol at endof-synthesis. The total time of synthesis, purification, and formulation was 26 min.

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