𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of [11C]LU 29-066, a 5-HT2 receptor antagonist

✍ Scribed by Mostafa Amokhtari; Kim Andersen; Meziane Ibazizène; Fabienne Gourand; François Dauphin; Louisa Barré

Publisher
John Wiley and Sons
Year
1999
Tongue
French
Weight
353 KB
Volume
42
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Rapid synthesis of [18F]SR46349B, a pote
Rapid synthesis of [18F]SR46349B, a potent and selective 5-HT2 receptor antagonist
✍ Pingzhong Tan; Joanna S. Fowler; Yu-Shin Ding; David J. Schlyer 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 483 KB

## Abstract F‐18 labeled SR46349B, a highly potent and selective 5‐HT~2~ receptor antagonist, was synthesized as a potential radioligand for PET studies of brain 5‐HT~2~ receptors. Nucleophilic aromatic substitution of __trans__‐1‐(2‐nitrophenyl)‐3‐(4‐methoxymethoxyphenyl)‐2‐propenone (10) with NCA

Synthesis and preliminary PET study of t
Synthesis and preliminary PET study of the 5-HT7 receptor antagonist [11C]DR4446
✍ Ming-Rong Zhang; Terushi Haradahira; Jun Maeda; Takashi Okauchi; Takayo Kida; Sh 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 118 KB

DR4446 (1-methyl-2a-[4-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)butyl]-2a, 3,4,5-tetrahydro-1H-benz[cd ]indole-2-one) is a potent 5-HT 7 receptor antagonist (K i ¼ 9:7 nM) with a high selectivity over other 5-HT family receptors (K i for 5-HT 1A : 770 nM; for other 5-HT receptors: >1000 nM). As

Synthesis and evaluation of [11C]RU40555
Synthesis and evaluation of [11C]RU40555, a selective glucocorticoid receptor antagonist
✍ Takahiro Matsuya; Hiroyuki Takamatsu; Yoshihiro Murakami; Akihiro Noda; Kazuhiko 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 224 KB

## Abstract We demonstrated the synthesis of carbon‐11 labeled 17‐__α__‐hydroxy‐11‐__β__‐/4‐/[methyl]‐[1‐methylethyl]‐aminophenyl/‐17__α__‐[prop‐1‐ynyl]esta‐4‐9‐diene‐3‐one (RU40555), a selective glucocorticoid receptor (GR) antagonist, and examined the __in vivo__ profile of [^11^C]RU40555. [^11^