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Highly efficient synthesis of [11C]PE2I, a selective radioligand for the quantification of the dopamine transporter using PET

✍ Scribed by Frédéric Dolle; Michel Bottlaender; Stéphane Demphel; Patrick Emond; Chantal Fuseau; Christine Coulon; Michele Ottaviani; Héric Valette; Christian Loc'h; Christer Halldin; Laurent Mauclaire; Denis Guilloteau; Bernard Maziere; Christian Crouzel

Publisher
John Wiley and Sons
Year
2000
Tongue
French
Weight
421 KB
Volume
43
Category
Article
ISSN
0022-2135

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SUMMARY In order to study the dopamine transporter by \(\mathrm{PET}\), we prepared ( \(E\) )-N-(3-bromoprop-2-enyl)\(2 \beta\)-carbomethoxy-3 \(\beta\)-(4'-tolyl) nortropane (PE2Br) and its radiobrominated analogue. PE2Br and \(\left[{ }^{76} \mathrm{Br}\right] \mathrm{PE} 2 \mathrm{Br}\) were synt