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Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter

✍ Scribed by Aloke K. Dutta; Maarten E.A. Reith; Bertha K. Madras


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
125 KB
Volume
39
Category
Article
ISSN
0887-4476

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[11C]Ξ²-CIT-FE, a radioligand for quantit
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The cocaine analogue P-CIT-FE (N-(2-fluoroethyl)-2~-carbomethoxy-3~-(4-iodopheny1)nortropane) was labeled with ' lC for positron emission tomography (PET) studies of the dopamine transporter. After intravenous administration to a cynomolgus monkey, ["CIP-CIT-FE accumulated in the striatum with a str